Grandma was introduced to the Disney comic universe by Al Taliaferro in the newspaper comic strips - as a picture in 1940, and in person in 1943. Over the years she has appeared in many comics including the popular graphic novel The Life and Times of Scrooge McDuck by Don Rosa.
She made her animated debut in the 1960 Wonderful World of Color episode "This is Your Life, Donald Duck", where she was voiced by June Foray. The episode depicted her great difficulty in raising Donald, a strong-willed and ill-tempered duckling from the moment he was hatched. She also made a non-speaking cameo in Mickey's Christmas Carol, as well can be spotted in background in episode of DuckTales "Horse Scents" Today Grandma can often be seen Mickey's and Friends stories.